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DeCS
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Descriptor English:
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Insulin Receptor Substrate Proteins
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Descriptor Spanish:
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Proteínas Sustrato del Receptor de Insulina
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Descriptor Portuguese:
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Proteínas Substratos do Receptor de Insulina
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Synonyms English:
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IRS Signaling Adaptor Proteins
Insulin Receptor Substrate-1
Insulin Receptor Substrate-1 Protein
Insulin Receptor Substrate-2
Insulin Receptor Substrate-2 Protein
Insulin Receptor Substrate-3
Insulin Receptor Substrate-3 Protein
Insulin Receptor Substrate-4
Insulin Receptor Substrate-4 Protein
Insulin Receptor Substrate 1
Insulin Receptor Substrate 1 Protein
Insulin Receptor Substrate 2
Insulin Receptor Substrate 2 Protein
Insulin Receptor Substrate 3
Insulin Receptor Substrate 3 Protein
Insulin Receptor Substrate 4
Insulin Receptor Substrate 4 Protein
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Tree Number:
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D12.644.360.024.301
D12.776.157.057.045
D12.776.476.024.382
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Definition English:
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A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling. |
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History Note English:
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2009(1992)
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Allowable Qualifiers English:
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Record Number:
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53148
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Unique Identifier:
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D055504
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Occurrence in VHL:
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Similar:
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DeCS CID-10 LILACS
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